Correlation of Placental Growth Factor with Pre-Eclampsia during Mid Trimester of Pregnancy: A Case Control Study at Liaquat University of Medical and Health Sciences, Pakistan
Published: November 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/44560.14284
Khalid Yousuf Memon, Ikram Din Ujjan, Nailla Yousuf, Syed Hasan Ala, Shabnam Rustamani, Fozia Shaikh, Abid Hussain Chang, Suha Mahrukh
1. Lecturer, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
2. Professor, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
3. Associate Professor, Department of Obstetrics and Gynaecology, Peoples Medical University of Medical and Health Sciences for Womens, Nawab Shah, Pakistan.
4. Assistant Professor, Department of Obstetrics and Gynaecology, Dow University of Health Sciences, Karachi, Pakistan.
5. Lecturer, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
6. Lecturer, Department of Biochemistry, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
7. Associate Professor, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
8. Final Year Student, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
Correspondence
Khalid Yousuf Memon,
Lecturer, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
E-mail: drmsarain@gmail.com
Introduction: Pre-Eclampsia (PE) is the common multisystem disorder which complicates the pregnancies 3-8% and a major cause of morbidity and mortality throughout the world.
Aim: To determine the correlation of placental growth factor with PE in mid trimester of pregnancy at Liaquat University of Medical and Health Sciences Jamshoro.
Materials and Methods: This Case-Control study was performed at Pathology Department with Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro/Hyderabad, during 12 months, from 6th February, 2017 to 5th February 2018. Pregnant women with mid trimester were enrolled in the study. Group A included females with PE, while Group B were normotensive females of same gestation. Their blood sample were collected and stored at -80°. Level of placental growth factor was measured on Elecsys system. Data was analysed via Statistical Package for the Social Sciences (SPSS) version 20.
Results: Total 384 PE females were selected and 50 females without hypertension were studied as control. Mean age of patients was 27.46±3.91 years. No significant variance was seen between mean of gestational age of patients and normal pregnant females; p-value 0.346. Mean of placental growth factor was insignificantly decreased 35.21±31.68 pg/mL among patients in contrast to normal women as 47.23±56.13 pg/mL, p=0.081. A negative correlation was found between blood pressure and placental growth factor, r-values -0.004 and -0.001, respectively.
Conclusion: It was concluded that serum placental growth factor was the poor marker for PE, as it showed weak negative correlation with PE.
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